Scleritis is inflammation of the sclera, the white fibrous tissue underneath the conjunctiva and episclera, and its blood vessels. It predominantly occurs in women, and its incidence increases with age. Scleritis can be idiopathic but is often related to underlying autoimmune disease. It is characterized by deep boring eye pain and presents as a red eye that does not blanch with instillation of 2.5% phenylephrine (Gerstenblith and Rabinowitz). Episodes of scleritis can result in thinner areas of sclera, presenting as a gray or blue patch of sclera. Gray patches of sclera were present in our patient’s left eye. However, active scleritis was easily ruled out due to the white and quiet appearance of the patient’s sclera and no intraocular inflammation. The gray patch of the sclera in our patient was deemed to most likely be scleral melanocytosis, a congenital gray-blue pigmentation of sclera not associated with systemic conditions. Oculodermal melanocytosis, also known as Nevus of Ota, involves the sclera and eyelids and is associated with an increased risk of uveal melanoma.
Sure it is, and that’s a very observant question. You can probably see that onstage. You can watch us perform and pick up on that dynamic: that Carl has to get in there; get between us. That’s no easy task, that’s for sure. We’re into our second year with Carl after a bit of a rotating thing with players coming in and out. Carl’s played every gig with us for over a year now. He’s locked in now and it’s been great.
The patient declined hospital admission and intravenous antibiotics. Instead, he was treated empirically with oral prednisone (20 mg) three times per day and amoxicillin/clavulanate potassium (875 mg/125 mg) twice a day and scheduled for follow-up in 24 hours. The patient was also given fluticasone 50 µg to keep the osteomeatal opening patent by administering two nasal sprays per day. He was also educated on nasal irrigation techniques. He was advised that if the condition worsened, surgical drainage of the sinuses would be necessary.
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La proposition de TVA à 0% sur les protections périodiques, parue dans Libé, concerne-t-elle les coupes menstruelles?
Last year she remembers arriving at the school gate about 07:30. A crowd of delirious first years were singing and chanting, and handing out sticky toffees known as "yeot", for good luck.
For Barrett, one of the most interesting neurological questions about salvia is how it interfaces with the claustrum. As detailed in a 2005 study, the “enigmatic” claustrum is a “thin, sheet-like neuronal structure…that is remarkable in that it receives input from almost all regions of the cortex and projects back to almost all regions of the cortex,” the wrinkly outermost region of the brain that plays a fundamental role in consciousness. According to Barrett, another notable feature of the claustrum is that it has the highest density of serotonin 2A and kappa opioid receptors in the brain, and both of these receptors are targeted by two very different classes of consciousness-altering hallucinogens.
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Some things are different, of course. Back then, I imagine, they might’ve had a band playing through the night, rather than Spotify hooked up to speakers. I imagine students might have dressed up for the night out; I imagine that going out dancing was the big night of the week. I think of how I might have fit in well, with that crowd from the ’50s, as I dance away my Wednesday night in well-loved, second-hand red heels and a bright orange flouncy skirt.
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This is salvia divinorum—arguably the strangest and least understood naturally occurring hallucinogen ever discovered.
During my IT GCSE I named all of my database files after my favourite bands. Led to my IT teacher giving me a half hour lecture about what the placebo effect was…
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